Alpha-GPC, also known as L-Alpha Glycerylphosphorylcholine or choline alfoscerate, is a choline supplement derived from soy or sunflower lecithin. It is highly bioavailable and easily crosses the blood-brain barrier, making it an ideal source of choline for cognitive benefits. Alpha-GPC serves as a precursor to acetylcholine, an essential neurotransmitter involved in memory, attention, and muscle contraction. It is rapidly absorbed by the body and supports overall cognitive function and cellular membrane integrity.

How Does Alpha GPC Function within the Brain?

Alpha GPC functions within the brain through multiple mechanisms to enhance cognitive function and overall brain health. Primarily, as a precursor to acetylcholine, a neurotransmitter crucial for memory and cognitive processes, Alpha GPC increases acetylcholine levels, thereby improving inter-neuronal communication efficiency. This leads to enhanced memory, learning, cognitive processing, and mental clarity. Additionally, Alpha GPC directly influences the development of cell membranes in the cerebral cortex, promoting optimal neuronal function and signaling. Mechanistically, Alpha GPC boosts acetylcholine synthesis and release in the brain, impacting memory, motivation, arousal, and attention. Furthermore, increased acetylcholine levels induced by Alpha GPC supplementation may lead to stronger signals for muscle contraction, contributing to increased force production.

In clinical trials, Alpha GPC has shown promise in preventing memory and attention impairment induced by substances like scopolamine, even in healthy individuals. Moreover, studies with Alzheimer's patients have demonstrated consistent improvements in cognitive function over time with Alpha GPC supplementation. Overall, Alpha GPC's multifaceted action on acetylcholine synthesis, neuronal membrane integrity, and muscle contraction signals collectively contribute to its beneficial effects on cognitive function and brain health.

Suggested Intake:

Alpha GPC contains roughly 40% choline content by its mass, meaning that 1 gram (1,000 milligrams) of Alpha GPC supplies close to 400 milligrams of choline. For enhancing cognitive functions, it is advised to consume between 300 to 1,200 milligrams of Alpha GPC daily.When used for clinical management of conditions such as Alzheimer's Disease, dementia, and related cognitive impairments, a daily dosage of up to 1,200 milligrams may be prescribed.

Side Effects:

Alpha GPC is naturally produced in the body, rendering it generally well-tolerated and safe for consumption. Although rare, potential side effects may include fatigue, headaches, nervousness, nausea, diarrhea, and gastrointestinal discomfort, often indicating an excess of choline in the body. Due to its energizing effects, Alpha GPC is best avoided in the evening to prevent sleep disturbances. However, a recent study published in 2021, involving over 12 million individuals aged 50 years or older who had used Alpha GPC for at least 10 years, revealed a 46% increased risk of stroke. Hence, while Alpha GPC is generally considered safe for short-term use, caution is advised regarding long-term usage.

Note that Alpha-GPC is also known as:

• Alpha-glycerylphosphorylcholine
• L-alpha-glycerophosphocholin
• glycerophosphocholine
• L-alpha-glyceryl-phosphorylcholine
• Choline Alphoscerate

Benefits：

• Improve memory and learning ability
• Restore the bioavailability of acetylcholine
• Restore and boost nerve growth factor receptors in the brain
• Increase growth hormones in all age groups
• Boost cognitive performance and memory in Alzheimer’s patients

Application

• Capsules
• Powder
• Gummies
• Liquid Drops