Oleoylethanolamide

Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. It is responsible for the feeling of satiety following meals.

OEA acts on a receptor called Peroxisome Proliferator-Activated Receptor Alpha (PPARα). When this receptor is activated in the intestines of rats, the animals consume less food. Research on rats shows that both injections and oral intake of OEA causes a reliable reduction in the amount of food eaten.

Limited human evidence suggests that OEA may be able to aid fat loss by acting on PPARα. It is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis. When this receptor is activated in fat tissue, energy expenditure increases.