Gamma-aminobutyric acid (GABA) is a neurotransmitter found in plants, animals, and microorganisms, as well as in certain foods and produced by the human body. It acts as the primary inhibitory neurotransmitter in the central nervous system, regulating the balance with the excitatory transmitter glutamate. A healthy brain maintains a critical balance of GABA and glutamate.

How does GABA work?

GABA exerts its effects through two natural receptors on nerve cells: GABA-A and GABA-B. When GABA binds to these receptors, it diminishes the responsiveness of the nerve cell, regulating the signals transmitted between neurons. By modulating neural signaling, GABA helps manage anxiety-related symptoms and prevents overstimulation of neurons, thereby promoting a state of calmness and relaxation.

Additionally, GABA influences brain health by altering brain wave activity. It decreases Beta brain waves associated with heightened alertness and concentration, while increasing Alpha brain waves linked to a relaxed state. By shifting the balance between these brain waves, GABA promotes a relaxed mental state and mitigates the negative effects of excessive concentration and stress. This modulation of brain wave activity contributes to improved stress management, enhanced immunity against stress-related effects, and supports overall mental well-being.

What are the benefits of GABA?

1. Sleep Regulation: GABA promotes restful sleep by inducing relaxation and regulating sleep cycles, enhancing both REM and non-REM stages.
2. Stress Reduction: Acting as a natural calming agent, GABA alleviates stress and anxiety by modulating neurotransmitter signals, fostering a sense of calmness and preventing overwhelm.
3. Metabolism and Appetite Control: GABA helps regulate hunger signals, promoting feelings of fullness and aiding in weight management by preventing overeating.
4. Blood Pressure Regulation: GABA serves as a natural ACE inhibitor, lowering blood pressure and reducing the risk of hypertension and associated cardiovascular complications.
5. Inflammation and Immune Support: GABA possesses anti-inflammatory properties and supports immune function, aiding in tissue healing and regulating immune responses.
6. Neuroprotection: GABA protects against nerve damage, mitigating neural inflammation and reducing the risk of degenerative neurological diseases, while also supporting cognitive function and brain health.

Recommended Dosage

The suggested daily dosage of GABA supplements for inducing relaxation or calmness ranges from 500 to 1000 mg. While some individuals experience an immediate sense of relaxation, others may require several weeks of consistent intake before noticing its effects.

What are the potential side effects of GABA supplements?

The side effects of GABA supplements have not been extensively studied, making it difficult to predict their exact outcomes. However, some commonly reported side effects include:

• Upset stomach
• Headache
• Drowsiness
• Muscle weakness

Reference：

[1] Hepsomali, Piril et al. “Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.” Frontiers in neuroscience vol. 14 923. 17 Sep. 2020

[2] Jin, Zhe et al. “GABA is an effective immunomodulatory molecule.” Amino acids vol. 45,1 (2013): 87-94.

[3] Oketch-Rabah, Hellen A et al. “United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA).” Nutrients vol. 13,8 2742. 10 Aug. 2021