Phosphatidylserine (PS) is a natural phospholipid compound synthesized in the body. It helps with neural communication in the brain, protects brain cells, and may help maintain cognitive sharpness. It is found in certain foods and is also offered as a dietary supplement, with PS supplements primarily sourced from soy or sunflower lecithin extracts.

How does Phosphatidylserine work in the Brain?

Phosphatidylserine (PS) and Phosphatidylcholine (PC) are essential phospholipids found in brain cell membranes, playing pivotal roles in maintaining cognitive health. While PC is mainly found in the outer layer of membranes, PS is essential in the inner layer, aiding in cell-to-cell signaling that is vital for neural communication and memory formation.

Benefits of Phosphatidylserine

Neuro-Optimization: PS helps maintain fluidity in brain cells, promoting neuroplasticity for memory retention and aiding in neuron repair and optimal brain functioning. Additionally, PS facilitates the flow of glucose and oxygen for enhanced mental energy.

Neurotransmitters: PS regulates neurotransmitters like dopamine and acetylcholine, boosting cognition, memory, mood, and reducing anxiety by increasing ACh levels in the brain through its choline content.

Neurogenesis: Working with DHA from Omega-3s, PS supports extended neuron survival and overall brain health, enhancing efficient brain cell function.

Side Effects

Phosphatidylserine (PS) is naturally synthesized within the body and is generally well tolerated and safe. It is regarded as non-toxic. However, some individuals may experience insomnia or stomach upset when exceeding the recommended dosage.

Recommended Dosage

A review article from 2015 stated that humans effectively absorb doses between 300 milligrams and 800 milligrams of phosphatidylserine per day. According to the Natural Medicine Comprehensive Database, the recommended therapeutic dosage for memory loss is 100 milligrams taken two or three times per day.


[1] Glade, Michael J, and Kyl Smith. “Phosphatidylserine and the human brain.” Nutrition (Burbank, Los Angeles County, Calif.) vol. 31,6 (2015): 781-6.

[2] Jingnan Chen, et al. “Phosphatidylserine: An overview on functionality, processing techniques, patents, and prospects.” Grain & Oil Science and Technology,Volume 6, Issue 4,2023

[3] Hirayama, S et al. “The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial.” Journal of human nutrition and dietetics : the official journal of the British Dietetic Association vol. 27 Suppl 2 (2014): 284-91.

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